SKIN FASTING EXOSOME SERUM
Resveratrol exosomes within this longevity serum act to trigger a fasting-mimicking mechanism in the skin to activate biomimetic autophagy, helping skin expel cellular waste. This results in a fortified skin barrier, metabolic efficiency, and a reduction in stress-related dullness. The formula employs a proprietary plant phenolic fraction technology to harness resveratrol exosomes from grape stem cells. By inducing "fasting-mimicking stress" during cultivation, the exosomes are concentrated with high-potency bio-active peptides that trigger the biomimetic autophagy, reducing lipofuscin – or aging waste – and neutralizing DNA damage. Alongside the exosomes’ repair, the formula’s proprietary complex of winter cherry and maca root adaptogens enhance skin's anti-stress resilience and restore homeostasis against fatigue. Meanwhile, the squalane-encapsulation system sees micro-capsules engineered to visually mirror the spherical structure of the exosomes. The capsules’ “burst-on-contact” technology creates a separation between the aqueous actives and protective lipids, for maximum potency and immediate barrier reinforcement.
Hall (Pavilion) and Stand Number: Hall 16A - Stand 42
This product is a finalist in the category Skin Care Formula of Cosmopack 2026
Launch Worldwide Date (First worldwide launch must have been launched within 12 months prior to the event). Date (Month/Day/Year)
Product Description (No Prototypes accepted)
Product Innovation
Claims & Benefits
Research, Clinical Tests & Trials Results (Safety & Dermatological)
1. In-vivo: Fasting-mimicking Effect (Skin Roughness) *Test completed
→ Test evaluation demonstrated a progressive reduction in skin roughness, with a -5% improvement at one month (T28) and a
significant -8% decrease by 56 days (T56), effectively refining skin texture
• Caucasian subjects (n=66, aged 40-65), placebo-controlled. Comparison between actual intermittent fasting (12-14 hours) + placebo application versus Resveratrol Exosome
application without fasting. Evaluations conducted on D28 and D56. Resveratrol Exosome 1%, applied twice daily to the entire face. Assessment of wrinkles, roughness, pigmentation
(erythema and melanin), and stratum corneum sampling.
2. In-vivo: Fasting-mimicking Effect (Skin Melanin Index) *Test completed→ Test assessment revealed a sequential decline in the melanin index, with a -4.1% decrease at one month (T28) and a
significant -6.1% attenuation by 56 days (T56), facilitating a visibly more radiant and uniform skin complexion
• Caucasian subjects (n=66, aged 40-65), placebo-controlled. Comparison between actual intermittent fasting (12-14 hours) + placebo application versus Resveratrol Exosome
application without fasting. Evaluations conducted on D28 and D56. Resveratrol Exosome 1%, applied twice daily to the entire face. Assessment of wrinkles, roughness, pigmentation
(erythema and melanin), and stratum corneum sampling.
3. In vitro: Lipofuscin Modulation *Test completed
→ In vitro assays indicate that Resveratrol Exosome suppresses lipofuscin accumulation in a dose-dependent manner, effectively
mitigating the formation of age-associated pigments by enhancing cellular homeostasis
• Human dermal fibroblasts. Progressive ageing for two months
• Control +: Metaformin (Hyoglycemic control) -100µM
• Lipofuscin accumulation
• Sudan black B (SBB) staining. Protocol based on Davan-Wetton et al., 2024
4. In vitro: Reduction in Senescence-Associated β-galactosidase (SA-β-Gal) Activity *Test completed
→ Resveratrol Exosomes effectively attenuate cellular senescence by downregulating the activity of Senescence-Associated
β-galactosidase (SA-β-Gal), a definitive biomarker of cellular aging
• Human dermal fibroblasts. Progressive ageing for two months
• Control +: Kojic Acid 500µM : Metformin (Hypoglyocemic control) ) -100µM
• SA-β-Galactosidase activity
• X-Gal activity detection kit.